Shopping Cart
- Remove All
Your shopping cart is currently empty
Zeaxanthin dipalmitate
😃Good
Catalog No. TN4773Cas No. 144-67-2
Alias Physalien
Zeaxanthin dipalmitate (Physalien) is a lutein carotenoid found in fruits with anti-inflammatory, hepatoprotective, and anti-oxidative stress activity that attenuates ethanol-induced liver injury.Zeaxanthin dipalmitate restores mitochondrial autophagy, a function that has been inhibited by ethanol intoxication. Zeaxanthin dipalmitate protects degenerated photoreceptors in the retina of mice and improves visual acuity in a mouse model of photoreceptor degeneration, and may be used in studies of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP).
Zeaxanthin dipalmitate
😃Good
Catalog No. TN4773Alias PhysalienCas No. 144-67-2
Zeaxanthin dipalmitate (Physalien) is a lutein carotenoid found in fruits with anti-inflammatory, hepatoprotective, and anti-oxidative stress activity that attenuates ethanol-induced liver injury.Zeaxanthin dipalmitate restores mitochondrial autophagy, a function that has been inhibited by ethanol intoxication. Zeaxanthin dipalmitate protects degenerated photoreceptors in the retina of mice and improves visual acuity in a mouse model of photoreceptor degeneration, and may be used in studies of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $183 | 35 days | |
| 5 mg | $793 | 35 days | |
| 10 mg | $1,430 | 35 days |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Zeaxanthin dipalmitate"
Hydroxychloroquine
Cited
2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
T9287118-42-3
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
- $30
Size
QTY
CitedPaeonol
Peonol
T2900552-41-0
Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
- $46
Size
QTY
Guanidine hydrochloride
Guanidinium chloride, Guanidine HCl, Aminoformamidine Hydrochloride, Aminoformamidine HCl
T041550-01-1
Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
- $29
Size
QTY
Naringin Cited
Naringoside
T059510236-47-2
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
- $35
Size
QTY
CitedStavudine
Sanilvudine, NSC 163661, d4T, BMY-27857
T14043056-17-5
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
ApoptosisAutophagyHIV ProteaseNOD-like Receptor (NLR)Nucleoside Antimetabolite/AnalogReverse Transcriptase
- $33
Size
QTY
Sodium 4-phenylbutyrate Cited
TriButyrate, Sodium Phenylbutyrate, Buphenyl
T15351716-12-7
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
- $38
Size
QTY
CitedValproic Acid
Cited
VPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic Acid
T706499-66-1
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
- $50
Size
QTY
Cited
ZD1839
T1181184475-35-2
Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation.
- $40
- $50
Size
QTY
CitedAceglutamide
α-N-Acetyl-L-glutamine, N2-Acetylglutamine
T07692490-97-3
Aceglutamide (N2-Acetylglutamine) is an acetyl derivative of the amino acid L-glutamine, used to improve memory.
- $29
Size
QTY
Taurine
2-Aminoethanesulfonic acid
T0022107-35-7
Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Taurine is involved in a number of processes related to energy expenditure and muscle function, and can treat fatigue and muscles as well as improve immune function.
- $41
Size
QTY
Salicylic acid
2-Hydroxybenzoic acid
T064969-72-7
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
- $33
Size
QTY
Curcumin Cited
Turmeric yellow, Natural Yellow 3, Indian Saffron, Diferuloylmethane
T1516458-37-7
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
- $30
Size
QTY
CitedSelect Batch
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Zeaxanthin dipalmitate (Physalien) is a lutein carotenoid found in fruits with anti-inflammatory, hepatoprotective, and anti-oxidative stress activity that attenuates ethanol-induced liver injury.Zeaxanthin dipalmitate restores mitochondrial autophagy, a function that has been inhibited by ethanol intoxication. Zeaxanthin dipalmitate protects degenerated photoreceptors in the retina of mice and improves visual acuity in a mouse model of photoreceptor degeneration, and may be used in studies of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP). |
| Targets&IC50 | P2X7 receptor:81.2 nM (kd), lipocalin receptor 1 (AdipoR1 ):533 nM (kd) |
| In vitro | Zeaxanthin dipalmitate directly interacted with P2X7 receptor (Kd=81.2 nM) and lipocalin receptor 1 (AdipoR1; Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate (1 µM; 2 h) was able to completely or partially reverse the down-regulation of Atg5, beclin-1, and LC3A/B by ethanol (250 mM) in BRL-3A cells, as well as up-regulation of p62 by ethanol, and partially restored ethanol-suppressed LC3B expression in BRL-3A cells. It also partially restored the viability and ethanol-induced caspase-3/7 activity of ethanol-inhibited BRL-3A cells, and restored the ethanol-induced inhibition of mitochondrial autophagy in BRL-3A cells. [1][2] |
| In vivo | Zeaxanthin dipalmitate (10 mg/kg orally once daily for two weeks) effectively reduced serum ALT and AST levels due to prolonged ethanol challenge in an AFLD model. In addition, this dose of Zeaxanthin dipalmitate was able to significantly attenuate tissue damage and slow down the extent of hepatocyte apoptosis (as assessed by caspase-3/7 activity) and inflammation (TNF-alpha) due to AFLD. In rd10 mice, a single intravitreal injection of Zeaxanthin dipalmitate (~4 μM) was able to improve their visual behavior and delay the degeneration of retinal photoreceptors. Also, this dose enhanced the light response of photoreceptors, bipolar cells, and retinal ganglion cells, and reduced the expression of genes associated with inflammation, apoptosis, and oxidative stress in rd10 mice. [1][2] |
| Alias | Physalien |
| Molecular Weight | 1045.69 |
| Formula | C72H116O4 |
| Cas No. | 144-67-2 |
| Smiles | C(=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=1C(C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC1C)\C)\C)/C)/C)\C=2C(C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC2C |
| Relative Density. | 0.96 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Zeaxanthin dipalmitate | purchase Zeaxanthin dipalmitate | Zeaxanthin dipalmitate cost | order Zeaxanthin dipalmitate | Zeaxanthin dipalmitate chemical structure | Zeaxanthin dipalmitate in vivo | Zeaxanthin dipalmitate in vitro | Zeaxanthin dipalmitate formula | Zeaxanthin dipalmitate molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.